What is Finasteride?
Finasteride is a medication for male pattern hair loss and benign prostatic hyperplasia. It works by inhibiting the enzyme 5-alpha-reductase, reducing dihydrotestosterone levels, a key factor in hair loss and prostate growth.
Post Finasteride Syndrome
Post Finasteride Syndrome (PFS) describes persistent sexual, neurological, and physical adverse reactions in patients who have taken finasteride and discontinued its use.
Common PFS Symptoms
Symptoms of PFS can include sexual dysfunction, depression, anxiety, cognitive impairment, and physical changes such as gynecomastia and muscle wastage, persisting after drug cessation.
PFS Incidence Rate
The exact incidence rate of PFS is unknown. Studies suggest a minority of users are affected, but underreporting may mean prevalence is underestimated.
Mechanism of PFS
The mechanism behind PFS isn't fully understood. Theories include persistent androgen receptor changes, neurosteroid deficiencies, and epigenetic alterations affecting gene expression.
Controversy and Research
PFS is controversial, with debates over its existence and extent. Ongoing research aims to elucidate PFS mechanisms, improve diagnosis, and explore potential treatments.
Managing PFS
There's no definitive cure for PFS. Management focuses on symptom relief through lifestyle changes, psychological support, and, in some cases, hormonal therapies or off-label drug use.
What does Finasteride inhibit?
5-alpha-reductase enzyme
Dihydrotestosterone directly
Prostate gland function
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