BRCA Genes Introduction
BRCA1 and BRCA2 are genes that produce tumor suppressor proteins. When mutated, they lead to a higher risk of breast, ovarian, and other cancers.
BRCA Mutation Prevalence
BRCA mutations are rare, affecting about 1 in 400 people. Prevalence varies by group; about 1 in 40 Ashkenazi Jews carry a BRCA mutation.
Cancer Risk Variability
Not all BRCA mutations equal: the location and type of mutation can affect cancer risk levels. Some mutations might not significantly increase risk.
Men and BRCA Mutations
While often associated with female cancers, BRCA mutations also increase male breast cancer risk and are linked to prostate and pancreatic cancers.
BRCA Beyond Cancer
Emerging research suggests BRCA mutations may affect cardiovascular health and cognitive functions, expanding the impact beyond cancer susceptibility.
Impact on Treatment
BRCA status can guide treatment choices. Some drugs, like PARP inhibitors, are more effective in patients with BRCA-related cancers.
Preventive Measures
Individuals with BRCA mutations may opt for increased surveillance, chemoprevention, or prophylactic surgeries to lower risk of developing cancer.
What do BRCA genes produce?
Tumor suppressor proteins
Hormones for growth
Blood cell enzymes
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